Fluorinated Organocatalysts
Bifunctional iminophosphorane/(thio)urea catalysts
Recently, bifunctional organocatalysts have enabled the development of highly stereoselective transformations due to their ability to simultaneously organize and activate electrophilic substrates through hydrogen bonding and pro-nucleophilic reagents through deprotonation. However, slow reaction rates and high catalyst loadings remain major limitations in this field. Additionally, some limitations persist regarding the compatible reaction partners with these catalysts.
In our laboratory, we are investigating the design and synthesis of new bifunctional iminophosphorane/(thio)urea catalysts containing a chiral trifluoromethyl group (F-BIMP), offering improved reactivity while maintaining high levels of enantiomeric control.
