2010-2002

1. Highly Diastereoselective alfa-Hydroxylation of Fox Chiral Auxiliary-Based Amide Enolates with Molecular Oxygen, Lubin, H. ; Tessier, A. ; Chaume, G. ; Pytkowicz, J. ; Brigaud, T. Org. Lett. 2010, 12, 1496-1499.

2. Synthesis of 2-Trifluoromethyl-1,3-oxazolidines as Hydrolytically Stable Pseudoprolines, Chaume, G. ; Barbeau, O. ; Lesot, P. ; Brigaud, T. J. Org. Chem. 2010, 75, 4135-4145.

3. Straightforward synthesis of enantiopure (R)- and (S)-trifluoroalaninol, Pytkowicz, J. ; Stephany, O. ; Marinkovic, S. ; Inagaki, S. ; Brigaud, T. Org. Biomol. Chem. 2010, 8, 4540-4542
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4. Posttranslationally modified peptides efficiently mimicking neoantigens : a challenge for theragnostics of autoimmune diseases, Nuti, F.; Peroni, E.; Real-Fernandez, F.; Bonache, M. A.; Le Chevalier-Isaad, A.; Chelli, M.; Lubin-Germain, N.; Uziel, J.; Rovero, P.; Lolli, F.; Papini, A. M. Biopolymers 2010, 94, 791-799.

5. Synthesis of alkynes and alkynyl iodides bearing a protected amino alcohol moiety as functionalized amino acids precursors, Ayed, C.; Picard, J.; Lubin-Germain, N.; Uziel, J.; Auge, J. Sci. China Chem. 2010, 53, 1921-1926.

6. Indium-mediated alkynylation of sugars : synthesis of C-glycosyl compounds bearing a protected amino alcohol moiety, Ayed, C.; Palmier, S.; Lubin-Germain, N.; Uziel, J.; Auge, J. Carbohydr. Res. 2010, 345, 2566-2570. 

1. Asymmetric aldol reactions using chiral CF₃-Oxazolidines (Fox) as chiral auxiliary,Tessier, A. ; Pytkowicz, J. ; Brigaud, T. J. Fluorine Chem., 2009, 130, 1140-1144

2. Iodocyclization of Chiral CF₃-Allylmorpholinones : A Versatile Strategy for the Synthesis of Enantiopure alfa-Tfm-Prolines and alfa-Tfm-Dihydroxyprolines, Caupène, C. ; Chaume, G. ; Ricard, L. ; Brigaud, T. Org. Lett. 2009, 11, 209-212

3. Convenient Synthesis of N-Terminal Tfm-Dipeptides from Unprotected Enantiopure alfa-Tfm-Proline and alfa-Tfm-Alanine, Chaume, G. ; Lensen, N. ; Caupène, C. ; Brigaud, T. Eur. J. Org. Chem. 2009, 33, 5717-5724

4. Huisgen Cycloaddition Reaction of C-Alkynyl Ribosides under Micellar Catalysis : Synthesis of Ribavirin Analogues, Youcef, R. A. ; Dos Santos, M. ; Roussel, S. ; Baltaze, J. -P. ; Lubin-Germain, N. ; Uziel, J. J. Org. Chem. 2009, 74, 4318-4323

5. Ionic liquid promoted atom economic glycosylation under Lewis acid catalysis, Augé, J. ; Sizun, G. Green Chem. 2009, 11, 1179-1183

1. Umpolung reactivity of difluoroenol silyl ethers with amines and amino alcohols. Application to the synthesis of enantiopure alfa-difluoromethyl amines and amino acids, Huguenot, F. ; Billac, A. ; Brigaud, T. ; Portella, C. J. Org. Chem. 2008, 73, 2564-2569

2. Concise access to enantiopure (S)- and (R)-α-trifluoromethyl pyroglutamic acids from ethyl trifluoropyruvate-based chiral CF3-oxazolidines (Fox), Chaume, G. ; Van Severen, M. -C. ; Ricard, L. ; Brigaud, T. J. Fluorine Chem. 2008, 129, 1104-1109

3. Fluorine••• and π•••Alcali Metal Interactions control in the Stereoselective Amide Enolates Alkylation using Fluorinated Oxazolidines (Fox) as Chiral Auxiliary : An Experimental and Theoretical Study, Sini, G. ; Tessier, A. ; Pytkowicz, J. ; Brigaud, T. Chem. Eur. J. 2008, 14, 3363-3370

4. Highly diastereoselective synthetic route to enantiopure β2-amino acids and γ-amino alcohols using a fluorinated oxazolidine (Fox) as chiral auxiliary, Tessier, A. ; Lahmar, N. ; Pytkowicz, J. ; Brigaud, T. J. Org. Chem. 2008, 73, 3970-3973

5. Direct C-glycosylation by indium-mediated alkynylation on sugar anomeric position, Lubin-Germain, N. ; Baltaze, J. -P. ; Coste, A. ; Hallonet, A. ; Lauréano, H. ; Legrave, G. ; Uziel, J. ; Augé, J. Org. Lett. 2008, 10, 725-728

6. A new rationale of reaction metrics for green chemistry. Mathematical expression of the environmental impact chemical processes, Augé, J. Green Chem. 2008, 10, 225-231

7. Ferrocenyl Glycopeptides as Electrochemical Probes to Detect Autoantibodies in Multiple Sclerosis Patients’ Sera, Real Fernández, F. ; Chamois-Colson, A. ; Bayardon, J. ; Nuti, F. ; Peroni, E. ; Meunier-Prest, R. ; Lolli, F. ; Chelli, M. ; Darcel, C. ; Jugé, S. ; Papini, A. M. Pept. Science 2008, 90, 488-495

8. Design glycopeptides with different β-turn types as synthetic probes for the detection of autoantibodies of multiple sclerosis, Carotenuto, A. ; Alcaro, A. C. ; Saviello, M. R. ; Peroni, E. ; Nuti, F. ; Papini, A. M. ; Novellino, E. ; Rovero, P. J. Med. Chem. 2008, 51, 5304-5309

1. The stereoselective synthesis of alfa-Tfm-amino acids from chiral CF₃ building blocks, Brigaud, T. ; Chaume, G., Pytkowicz, J. ; Huguenot, F. Chim. Oggi 2007, 25(Supl), 8-10

2. Cyclic allyl carbamates in stereoselective syn SE’ processes : approach to sarcodictyins and eleutherobin, Dhulut, S. ; Bourin, A. ; Lannou, M.-I. ; Fleury, E. ; Lensen, N. ; Chelain, E. ; Pancrazi, A. ; Ardisson, J. ; Fahy, J. Eur. J. Org. Chem. 2007, 31, 5235-5243

3. La chimie au coeur du développement durable : un message à faire passer dans l’enseignement et la société, Auge, J. L’Actual. Chim. 2007, 314, 44-50

4. Recent Advances in Indium-Promoted Organic Reactions, Auge, J. ; Lubin-Germain, N. ; Uziel, J. Synthesis 2007, 1739-1764

5. Ferrier-Type Alkynylation Reaction Mediated by Indium, Lubin-Germain, N. ; Hallonet, A. ; Huguenot, F. ; Palmier, S. ; Uziel, J. ; Auge, J. Org. Lett. 2007, 9, 3679-3682

1. Concise synthesis of enantiopure alfa-trifluoromethyl alanines, diamines and amino alcohols via the Strecker-type reaction, Huguenot, F. ; Brigaud, T. J. Org. Chem. 2006, 71, 7075-7078

2. Straightforward synthesis of (S)- and (R)-alfa-trifluoromethyl proline from chiral oxazolidines derived from ethyl trifluoropyruvate, Chaume, G., Van Severen, M.-C., Marinkovic, S. ; Brigaud, T. Org. Lett. 2006, 8, 6123-6126

3. Convenient asymmetric synthesis of beta-trifluoromethyl-beta-amino acid, beta-amino ketones and gama-amino alcohols via Reformatsky and Mannich type reactions from 2-trifluoromethyl-1,3-oxazolidines, Huguenot, F. ; Brigaud, T. J. Org. Chem. 2006, 71, 2159-2162

4. Chiral 2-trifluoromethyl-4-phenyloxazolidine : A novel highly performing chiral auxiliary for amides alkylation, Tessier, A. ; Pytkowicz, J. ; Brigaud, T. Angew. Chem. Int. Ed. Engl. 2006, 45, 3677-3681

5. Gram-Scale Preparation of a p-(C-Glucopyranosyl)-L-phenylalanine Derivative by a Negishi Cross-Coupling Reaction, Ousmer, M. ; Boucard, V. ; Lubin-Germain, N. ; Uziel J. ; Auge, J. Eur. J. Org. Chem. 2006, 1216-1221

6. Indium-Mediated Alkynylation in C-Glycoside Synthesis, Picard, J. ; Lubin-Germain, N. ; Uziel J. ; Auge, J. Synthesis 2006, 979-982

7. Mild synthesis of beta-amino-alfa,alfa-difluoroketones from acylsilanes and trifluoromethyltrimethylsilane in a one-pot imino aldol reaction, Jonet, S. ; Cherouvrier, F. ; Brigaud, T. ; Portella, C. Eur. J. Org. Chem. 2005, 4304-4312

8. Highly diastereoselective addition of organometallic reagents to a trifluoroacetaldehyde hydrazone derived from (R)-N-benzylphenylglycinol, Fries, S. ; Pytkowicz, J. ; Brigaud, T. Tetrahedron Lett. 2005, 46, 4761-4764

9. On-resin head-to-tail cyclization of cyclotetrapeptides : optimization of crucial parameters, Alcaro, M. C. ; Sabatino, G. ; Uziel, J. ; Chelli, M. ; Ginanneschi, M. ; Rovero, P. ; Papini, A. M. J. Pept. Sci. 2004, 10, 218

10. C-Glycosylated Phenylalanine Synthesis by Palladium-Catalyzed Cross-Coupling Reactions, Boucard, V. ; Larrieu, K. ; Lubin-Germain, N. ; Uziel, J. ; Augé, J. Synlett 2003, 1834-1837

11. An Alternative Procedure in the Takai Reaction Using Chromium(III) Chloride Hexahydrate as a Convenient Source of Chromium(II), Augé, J. ; Boucard, V. ; Gil, R. ; Lubin-Germain, N. ; Picard, J. ; Uziel, J. Synth. Commun. 2003, 33, 3733-3739

12. Indium-catalyzed Barbier allylation reaction, Augé, J. ; Lubin-Germain, N. ; Marque, S. ; Seghrouchni, L. J. Organomet. Chem. 2003, 679, 79-83

13. NMR enantiodifferentiation of triphenylphosphonium salts by chiral hexacoordinated phosphate anions, Hebbe, V. ; Londez, A. ; Goujon-Ginglinger, C. ; Meyer, F. ; Uziel, J. ; Jugé, S. ; Lacour, J. Tetrahedron Lett. 2003, 44, 2467-2471

14. Indium-mediated formation of propargyl ketones from aldehydes or acyl chlorides, Augé, J. ; Lubin-Germain, N. ; Seghrouchni, L. Tetrahedron Lett. 2003, 44, 819-821

 

15. Efficient synthesis of beta-halogeno protected -alanines and their beta-phosphonium derivatives, Meyer, F. ; Laaziri, A. ; Papini, A. M. ; Uziel, J. ; Jugé, S. Tetrahedron : Asym., 2003, 14, 2229-2238

 

16. Lewis acid activation of chiral 2-trifluoromethyl-1,3-oxazolidines. Application to the stereoselective synthesis of trifluoromethylated amines, alfa- and beta-amino acids, Lebouvier, N. ; Laroche, C. ; Huguenot, F. ; Brigaud, T. Tetrahedron Lett. 2002, 43, 2827-2830

 

17. Indium-mediated carbonyl alkynylation, Augé, J. ; Lubin-Germain, N. ; Seghrouchni, L. Tetrahedron Lett. 2002, 43, 5255-5256

 

18. A convenient solvent-free preparation of 1,3,5-trioxanes, Augé, J. ; Gil, R. Tetrahedron Lett. 2002, 43, 7919-7920

 

19. Diastereoselective Alkylation of Schiff Bases for the Synthesis of Lipidic Unnatural Fmoc-Protected alfa-Amino Acids, Papini, A. M. ; Nardi, E. ; Nuti, F. ; Uziel, J. ; Ginanneschi, M. ; Chelli, M. ; Brandi, A. Eur. J. Org. Chem. 2002, 2736-2741